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IC‐P‐105: Basal forebrain and hippocampus as predictors of conversion to Alzheimer's disease in patients with mild cognitive impairment: A multicenter DTI and volumetry study
Author(s) -
Brüggen Katharina,
Dyrba Martin,
Barkhof Frederik,
Hausner Lucrezia,
Filippi Massimo,
Nestor Peter,
Hauenstein Karlheinz,
Klöppel Stefan,
Grothe Michel J.,
Kasper Elisabeth,
Teipel Stefan J.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.127
Subject(s) - basal forebrain , hippocampus , dementia , atrophy , medicine , magnetic resonance imaging , grey matter , psychology , alzheimer's disease , diffusion mri , hippocampal formation , cardiology , neuroscience , white matter , disease , cholinergic , radiology
deviations or individual numbers of with biomarker positive or negative status at baseline and corresponding numbers of patients with conversion to AD at follow-up of each study were extracted. We calculated the effect sizes of each biomarker expressed as Hedge’s g for outcome measure. Results:Thirty MRI studies and 10 amyloid PET imaging studies were retrieved. In this meta-analysis, of the 2444 participants, 1038 developed AD. Based on the forty included studies, the mean converting proportion was 42%. The effect size (Hedge’s g) of MRI for predicting conversion to AD was 0.83 (95% confidential interval [CI] 0.66-1.01) and amyloid PET imaging was 1.31(95% CI 0.98-1.45). (p<0.001) However, the effect size of entorhinal cortical volumetric measure of MRI was 1.12 (95% CI 0.80-1.45) and it was not significantly different with amyloid PET imaging. (P1⁄4 0.423). Conclusions:This meta-analysis showed amyloid PET imaging performs better than structural MRI in the prediction of conversion to AD in patients with MCI. And also, it suggests that entorhinal cortical volume measure in MRI is a compatible technique with amyloid PET imaging for prediction of progression from MCI to AD. Our study suggest volumetric MRI is also useful in clinical practice.