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IC‐P‐094: Tract‐specific white matter hyperintensities disrupt the default mode network in Alzheimer's disease
Author(s) -
Taylor Alexander N.W.,
Kambeitz-Ilankovic Lana,
Gesierich Benno,
Simon-Vermot Lee,
Caballero Miguel Ángel Araque,
Müller Sophia,
Heshung Liu,
Ertle-Wagner Birgit,
Buerger Katharina,
Weiner Michael W.,
Dichgans Martin,
Duering Marco,
Ewers Michael
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.115
Subject(s) - default mode network , hyperintensity , dementia , white matter , neuroscience , atrophy , cognition , psychology , neurodegeneration , cardiology , medicine , magnetic resonance imaging , disease , radiology
without pathological confirmation, and often without betweendisease comparisons. In this study, we aim to identify patterns of atrophy that differentiate between pathologically confirmed Alzheimer’s disease (AD), dementia with Lewy bodies (DLB) and frontotemporal lobar degeneration (FTLD), using retrospective data from a large sample of patients who attended clinics in three different European centres (VUMC-Amsterdam, DRC-London, IAH-Newcastle) and had post mortem confirmation of diagnosis. Methods: Voxel based morphometry, using SPM12, was applied to T1-weighted volumetric MRI scans from 182 patients with pathologically confirmed dementia (100 AD, 54 FTLD, 28 DLB) and 73 normal control (NC) subjects. Images were segmented into grey matter, white matter and CSF, spatially normalised using Dartel, and smoothed (full-width half-maximum 60mm). Volume changes between groups were analysed using a single General Linear Model, which included age, gender, total intracranial volume and disease duration. Statistical significance of group differences was corrected for multiple comparisons (family wise error rate p<0.05). Results:Differences in atrophy between each pathology group and the NC group are shown in Figure 1. The AD group showed greater volume loss posteriorly in the region of the posterior cingulate sulcus and the right central sulcus when compared with FTLD (Fig.2/Fig.3). Conversely, the FTLD group demonstrated greater atrophy in the region of the superior rostral and cingulate gyrus, extending out to the orbitofrontal gyrus and the insula, and back towards the anterior temporal lobe when compared with the AD group (Fig.2/Fig.3). The comparison between the FTLD and DLB groups was broadly similar but with more distinct differences in the left hippocampus, with the FTLD group showing greater atrophy in this region. Little difference was found between the AD and DLB groups (Fig.2). Conclusions:Distinct patterns of atrophy derived from post mortem confirmed cases can help distinguish between different dementia pathologies and could guide routine visual assessment, maximising the diagnostic information available from clinical T1-weighted MRI.