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IC‐P‐086: Intrinsic connectivity of hippocampal subfields in normal elderly and its disturbance in MCI patients
Author(s) -
Flores Robin,
Mutlu Justine,
Bejanin Alexandre,
Tomadesso Clémence,
Landeau Brigitte,
Mézenge Florence,
Sayette Vincent,
Eustache Francis,
Chételat Gaël
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.107
Subject(s) - subiculum , hippocampal formation , neuroscience , hippocampus , dentate gyrus , entorhinal cortex , orbitofrontal cortex , limbic lobe , functional connectivity , posterior cingulate , psychology , cortex (anatomy) , medicine , cognition , prefrontal cortex
relationship of Ab with memory among CN. Inferior temporal tau demonstrates the strongest relationship with memory, consistent with the hypothesis that spread of tau into neocortex (Braak Stage III) may signal impending cognitive impairment. Higher Ab is associatedwith higher tau, and among the PiB+ group, higher tau appears to be particularly deleterious to memory function. These findings are consistent with the hypothetical model that Ab may accelerate neocortical tau pathology and that tau is more proximal to memory decline.