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P3‐140: Age differences in the association of white matter lesions with the occurrence of dementia: The memento cohort
Author(s) -
Dufouil Carole,
Chupin Marie,
Auriacombe Sophie,
Savarieau Helen,
Dubois Bruno,
Pasquier Florence,
Blanc Frederic,
Hugon Jacques,
Ha Olivier,
Gabelle Audrey,
Ceccaldi Mathieu,
Beauchet Olivier,
Salmon Pierre Krolak,
David Renaud,
Rouaud Olivier,
Godefroy Olivier,
Belin Catherine,
Rouch Isabelle,
Wallon David,
Benetos Athanase,
Paccalin Marc,
Sauvée Mathilde,
Fillon Ludovic,
Hommet Caroline,
Sellal François,
Vercelletto Martine,
Jalenques Isabelle,
Gentric Armelle,
Vandel Pierre,
Bouteloup Vincent,
Operto Gregory,
Thomas-Anterion Catherine,
Belliard Serge,
Mangin Jean-Francois,
Ousset Pierre Jean,
Chene Geneviève
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1008
Subject(s) - dementia , cohort , medicine , hyperintensity , hazard ratio , vascular dementia , clinical dementia rating , cognitive decline , atrophy , cohort study , white matter , magnetic resonance imaging , gerontology , pediatrics , confidence interval , disease , radiology
Background:Florbetapir PET imaging has been validated in autopsy studies as reflecting the presence and quantity of amyloid pathology. This imaging has promise as a potential biomarker for AD and may allow the identification of individuals in the preclinical stages of the illness. If a sensitive screen for amyloid status could be developed this could enrich the enrollment of clinical trials for AD, thus reducing cost and participant burden. Our aim for the current study was to use item analysis of a broad cognitive battery to identify a set of items that would maximally predict cerebral amyloid pathology. Methods:The KU Self-Regulation and Cognitive Control Questionnaire (SRCCQ) is a 20-Item self-report questionnaire that measures changes in a participants’ metamemory for self-regulatory behaviors. Participants were asked to rate each item on the basis of change in current functional ability compared to five years ago and severity of current problems. We developed the SRCCQ to select items that produce good sensitivity to amyloid pathology. Sixty participants completed a lengthy self-report measure during their initial visit at the at the University of Kansas Alzheimer’s Disease Center. All participants also underwent PET imaging to evaluate amyloid pathology. Discriminant item analysis was conducted to examine sensitivity of the SRCCQ in detecting amyloid pathology. Results: SRCCQ measure showed 83% sensitivity to amyloid status and 67% overall accuracy detection. Item analysis revealed that highly predictive items on the SRCCQ were conceptually interrelated; most sampled similar facets of self-regulatory behaviors. Notably subjective memory complaints did not discriminatewell in this sample of participants. Conclusions:There is limited progress in the area of early detection screening tools for AD. Strong screening measures that come in the form of questionnaires and self-reports would greatly benefit busy primary care settings where time and resources are limited. Developing a simple screening tool that identifies participants with elevated cerebral amyloid bridges the gap between effective screening tolls and busy primary care settings. Items on the SRCCQ focused on self-regulatory behaviors which demonstrated good sensitivity to amyloid status. Measuring self-regulation and metamemory will be important for developing screening tools used in secondary prevention initiatives.