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P3‐137: Microstructural white matter integrity and risk of mortality
Author(s) -
Sedaghat Sanaz,
Cremers Lotte G.M.,
Groot Marius,
Hofman Albert,
Lugt Aad,
Franco Oscar H.,
Dehghan Abbas,
Ikram M. Arfan,
Vernooij Meike W.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1005
Subject(s) - white matter , fractional anisotropy , medicine , hazard ratio , proportional hazards model , population , risk of mortality , cardiology , confidence interval , magnetic resonance imaging , environmental health , radiology
p<0.006), which was significantly correlated with Digit Span Test performance (i.e. working memory) at 12 months (p<0.02) and BMI (p<0.001). Conclusions:Supporting evidence that report older individuals with higher BMI had less observable amyloid deposition within the DMN, we found elevated BMI indirectly lead to lower task-state DMN connectivity, which, in turn, lead to better performance on Digit Span Test. This suggests DMN connectivity mediates and suppresses the effect of BMI on cognitive function, and may be involved in compensatory processes in older adults.