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P3‐136: How does higher bmi preserve cognition among older adults? a 12‐month exploratory neuroimaging study
Author(s) -
Hsu Chun Liang,
Voss Michelle W.,
Best John R.,
Handy Todd C.,
Madden Kenneth,
Liu-Ambrose Teresa
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.1004
Subject(s) - overweight , neuroimaging , body mass index , medicine , dementia , cognition , cognitive decline , prospective cohort study , default mode network , obesity , gerontology , psychology , psychiatry , disease
(GDS) (p<0.0001), younger age (p1⁄40.003), and better socioeconomic status (Hollingshead) (p1⁄40.001) were associated with greater Purpose in Life (R1⁄40.29, p<0.0001 for the overall model). The cognitive factor scores were not retained in the model. In the second model, greater FDG metabolism (p1⁄40.008), younger age (p1⁄40.03), and better socioeconomic status (p<0.0001) were associated with greater Purpose in Life (R1⁄40.12, p<0.0001 for the overall model). Other imaging biomarkers and interactions were not retained in the model. Conclusions: Our findings support a relationship between fewer depressive symptoms and greater Purpose in Life. Moreover, the association of Purpose in Life with greater FDG metabolism, a marker of brain reserve, suggests that Purpose in Life may be an indicator of both better mental health and brain function.