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IC‐P‐068: The relationship of cognition, cognitive reserve, and in vivo tau and amyloid burden
Author(s) -
Rentz Dorene M.,
Mormino Elizabeth C.,
Amariglio Rebecca,
Papp Kathryn V.,
Schultz Aaron P.,
Sperling Reisa A.,
Johnson Keith A.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.089
Subject(s) - pittsburgh compound b , beta (programming language) , positron emission tomography , dementia , medicine , amyloid beta , psychology , temporal lobe , cognition , cognitive decline , nuclear medicine , cardiology , neuroscience , disease , computer science , epilepsy , programming language
nodes, before and after adjusting for IRS-1 expression (Fig.1). Higher pS312-IRS-1 was associated with lower lowto mediumfrequency spectral power of anterior DMN (Fig.2.B.C.). Higher pY-IRS-1 was associated with higher low-frequency spectral power of anterior DMN, higher mediumto high-frequency spectral power of posterior and ventral DMN, and spatially restricted posterior DMN (Fig.2.D.E.F.G). Conclusions:Novel exosomal brain IR biomarkers are associated with cognitive performance, brain atrophy in areas preferentially affected by AD pathology, and DMN resting state activity. These findings lend external validity to novel biomarkers of brain IR in AD and emphasize the importance of brain insulin signaling and glucose metabolism for AD pathogenesis. The NIA Intramural Research Program supported the study.