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IC‐P‐066: Systems fail before molecules spread: A cascading failure model of Alzheimer's disease
Author(s) -
Jones David T.,
Gunter Jeffrey L.,
Radford Jonathan Graff,
Boeve Bradley,
Knopman David S.,
Petersen Ronald C.,
Weiner Michael W.,
Jack Clifford R.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.087
Subject(s) - neuroscience , default mode network , disease , conceptualization , neurodegeneration , neuroimaging , cognition , psychology , computer science , medicine , artificial intelligence , pathology
Triangulated surfaces were geneterated to contour the most likely voxels for each structure. This atlas was mapped diffeomorphically onto each scan, and atrophy in aMCI patients relative to controls was quantified through local change in surface area, a technique known as surface diffeomorphometry. Regions with significant differences between groups were identified using permutation testing, controlling for false positives at 5% familywise error rate. Results: Anatomical changes were detected, including atrophy in the transentorhinal / lateral-entorhinal region (p < 1e-6). Conclusions:This atlas based method for probabilistically identifying topographic changes in the MTL identified regions of atrophy consistent with Braak staging for early Alzheimers disease. This method may also be useful for following the longitudinal progression of disease in the context of a clinical trial.