Premium
IC‐P‐061: Frequency and distribution of cerebral microbleeds in dementia with lewy bodies
Author(s) -
Sarro Lidia,
Gungor Ipek,
Radford Jonathan Graff,
Zuk Samantha M.,
Tosakulwong Nirubol,
Przybelski Scott A.,
Boeve Bradley,
Ferman Tanis J.,
Smith Glenn E.,
Knopman David S.,
Filippi Massimo,
Petersen Ronald C.,
Jack Clifford R.,
Kantarci Kejal
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.082
Subject(s) - dementia with lewy bodies , dementia , medicine , superficial siderosis , cerebral amyloid angiopathy , microangiopathy , population , nuclear medicine , pathology , disease , diabetes mellitus , endocrinology , environmental health
Background: Cerebrovascular disease is a known risk factor for cognitive decline among elderly and contributes to dementia in patients with Alzheimer’s disease (AD). A higher frequency of cerebral infarcts has been described in patients with dementia, however little is known about the frequency of cerebral infarcts in patients with Dementia with Lewy Bodies (DLB). Our objective was to assess the frequency of cortical and subcortical infarcts in a cohort of DLB patients compared to cognitively normal controls.Methods: Patients with probable DLB (n1⁄483) with median (IQR) age of 72 (67-77) years, whowere consecutively recruited to the Mayo Clinic Alzheimer’s Disease Research Center and underwent 3T MRI examination were included. Fluid-attenuated inversion recovery (FLAIR) MRI scans were assessed for the presence of small cortical (<1cm), large cortical, and subcortical infarcts. Frequency of infarcts in patients with probable DLB was compared to frequency of infarcts in age and sex matched cognitively normal controls (CN; n1⁄483) from the population-based Mayo Clinic Study on Aging. AChi-squared test was performed to detect the difference in frequency of infarcts among the two groups. Results:A total of 22 patients with probable DLB (27%) and 24 CN participants (29%) were identified as having at least one cerebral infarct, revealing no significant difference among the two groups (p1⁄40.73). Specifically, no differences were found in the proportion of small cortical (DLB: 2%; CN: 2%), large cortical (DLB: 4%; CN: 5%), or subcortical infarcts (DLB: 25%; CN: 24%), among patients with probable DLB versus CN (p>0.99). (Figure). Conclusions: In comparing probable DLB patients to age and sex matched CN subjects from a population based cohort, we found a striking similarity in frequency of cerebral infarcts regardless of size and localization.