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IC‐P‐059: Is arterial spin labeling a potential biomarker for early stage lewy body spectrum diseases?
Author(s) -
Steinberg Susanne Inez,
Vidorreta Marta,
Zhang Tianhao,
Davatzikos Christos,
Detre John,
Wolk David,
Leopold Norman,
Liang Tsao-Wei
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.080
Subject(s) - cerebral blood flow , cardiology , biomarker , medicine , voxel , nuclear medicine , arterial spin labeling , white matter , pathology , magnetic resonance imaging , audiology , radiology , chemistry , biochemistry
Background: Hypoperfusion/hypometabolism in parietal-occipital regions has been consistently reported in Lewy Body Spectrum Diseases (LBSD) using Arterial Spin Labeling (ASL-MRI) and FDGPET respectively regardless of the severity of cognitive or motor impairment. Herewe use optimally-discriminative voxel-based analysis (ODVBA) to identifydifferences incerebral bloodflood (CBF) in patients with Mild Cognitive Impairment (MoCAMean Score1⁄4 24) and Hahn & Yahr Stage II motor symptoms) versus controls to determine whether ASL may be a suitable biomarker for early stage LBSD.Methods: 22 healthy controls (HC) (15 F; 7366 years) and 16 LBSD patients (5 F; 7068 years) were scanned on at 3T using a 32channel head array. Anatomical images were acquired, followed by resting-state ASL consisting of 80 label-control pairs acquired with pseudo-continuous labeling, background suppression and singleshot 3D RARE stack-of-spirals readout. CBF maps were computed using a modified one-compartment model, normalizing absolute mapswith each subject’smean graymatter value to generate relative CBF maps, then normalizing to MNI space using SPM8 DARTEL toolbox and smoothed with FWHM1⁄48mm for group analysis. Linear correlations between whole-brain mean CBF and age and sex were evaluated and mean relative CBF differences between patients and controls were assessed using ODVBA; P value was set to p< 0.001, uncorrected. Results:Whole brain mean CBF was negatively associated with increasing age (p1⁄40.055) and positively associated with female sex p1⁄40.004. LBSD patients demonstrated decreased relative CBF compared to controls in the left parieto-occipital area (Fig.1A) including superior and inferior parietal gyrus, middle occipital gyrus, and angular gyrus; in more lateral regions left (Fig.1B) and right (Fig.1C) inferior occipital gyrus, and in the prefrontal region right middle frontal gyrus (Fig. 1D). LBSD group