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IC‐P‐018: Critical appraisal of the appropriate use criteria: Effect on diagnosis and patient care
Author(s) -
Apostolova Liana G.,
Haider Janelle,
Goukasian Naira,
LeClair Holly,
Chételat Gaël,
Rabinovici Gil D.,
Ringman John M.,
Kremen Sarah,
Restrepo Lucas,
Mendez Mario,
Silverman Daniel
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.038
Subject(s) - medicine , dementia , pittsburgh compound b , nuclear medicine , area under the curve , cerebral amyloid angiopathy , pathology , gastroenterology , disease
Background: A couple of population studies demonstrated that elderly with depression have lower plasma amyloid-b 42 (Ab42) than those without depression, and so called “amyloid depression hypothesis” (i.e., the hypothesis that cerebral amyloid deposition is related to late-life depression) was proposed. This study aimed to investigate the relationship between global cerebral Ab burden and depressive symptoms in elderly individuals with normal cognition (NC), amnestic mild cognitive impairment (MCI) and Alzheimer’s disease dementia (AD). Methods: Twenty-six NC, 23 MCI and 27 AD individuals were recruited. Subjects with history of major depressive episode or stroke were excluded. All subjects received three-dimensional volumetric 3T MRI, Pittsburgh Compound B (PiB)-positron emission tomography (PET) and comprehensive clinical evaluation including vascular burden assessment. Depressive symptoms were measured using Geriatric Depression Scale (GDS) and Hamilton Depression Rating Scale (HAM-D). Results: There were significant group differences of GDS and HAM-D scores among diagnostic groups, and post-hoc tests showed that AD had significantly higher GDS and HAM-D scores than NC (see Table). However, multiple linear regression analysis controlling for age, gender, diagnostic group, and vascular burden did not reveal that global cerebral Ab burden measured by PiBPET was associated with GDS or HAM-D scores. In subgroup analyses for each diagnostic group, we did not find any significant associations between global cerebral Ab burden and GDS or HAM-D scores after controlling age, gender and vascular burden. Conclusions:Our results did not support “amyloid depression hypothesis”, while the relationship between diagnostic group and depression scores implied that late-life depression might be associated with overall brain degeneration.