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IC‐04‐05: Multisite hippocampal subfields reproducibility: A european 3T study
Author(s) -
Marizzoni Moira,
Nobili Flavio,
Didic Mira,
Bartres David,
Fiedler Ute,
Schönknecht Peter,
Payoux Pierre,
Beltramello Alberto,
Soricelli Andrea,
Parnetti Lucilla,
Tsolaki Magda,
Rossini Paolo Maria,
Scheltens Philip,
Bordet Regis,
Blin Olivier,
Frisoni Giovanni Battista,
Jovicich Jorge
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.019
Subject(s) - subiculum , reproducibility , hippocampal formation , dentate gyrus , hippocampus , nuclear medicine , medicine , neuroscience , pathology , chemistry , biology , chromatography
values), longitudinal plausibility (frequency of implausible apparently-decreasing within-subject trajectories), and group separability (AUROC of predicting unlikely vs. likely PiB accumulators from slope values). Results: 82/180 methods achieved at least 0.90 performance on all criteria; differences between the best performing methods were not significant. In general, sharply-segmented GM segmentations outperformed broader ones. SPM vs Freesurfer had mixed tradeoffs. Reference regions using supratentorial WM were highly reliable but performed poorly on plausibility criteria. Cerebellar GM was outperformed by cerebellar WM, whole cerebellum, crus, and pons, which were all roughly equivalent. Methods with PVC were each better or not significantly worse than those without. Conclusions: Our results support the use of PVC, narrow GMsegmentation targets, and whole-cerebellum, cerebellum-WM, crus, or pons reference regions for SUVR calculations.