Premium
IC‐04‐01: Cortical capillary dysfunction in patients suspected of Alzheimer's disease
Author(s) -
Eskildsen Simon Fristed,
Gyldensted Louise,
Nagenthiraja Kartheeban,
Hansen Mikkel Bo,
Dalby Rikke Beese,
Frandsen Jesper,
Rodell Anders,
Gyldensted Carsten,
Jespersen Sune Nørhøj,
Mouridsen Kim,
Brændgaard Hans,
Østergaard Leif
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.06.015
Subject(s) - magnetic resonance imaging , precuneus , cardiology , cerebral blood flow , medicine , statistical parametric mapping , perfusion , nuclear medicine , pathology , radiology , functional magnetic resonance imaging
sporadic AD, studies have shown that early perfusion frames of amyloid imaging with [11C]-Pittsburgh Compound B PiB (ePiB) correlatewell with glucose metabolism (Rostomian et al., 2011). Here, we evaluatedwhether ePiB is a reasonable surrogatemarker for synaptic dysfunction, in comparison to glucose metabolism hypometabolism, and how ePiB changes with the disease progression.Methods:DIAN participants (n1⁄4110), including 65 asymptomatic and symptomatic mutation carriers (MC), underwent full dynamic PiB-PET and also had [18F]-fluorodeoxyglucose (FDG) PET and volumetric brain MRI. The MRI was used to register the PET images. A standardized uptake value ratio (SUVR) from MR segmented PiB and FDG regions. An ePiB image with 1-9 min time frames was selected. Voxel-wise spatial correlation between FDG and ePiB was performed for each participant. The mutation and cognitive status were taken into account in the analyses. For each imaging modality, relationship with EYO was evaluated with linear mixed models on specific regions such as inferior parietal and precuneus cortices. Results:FDG and ePiB were visually similar and showed high spatial correlation with an average of 0.860.04 regardless of the mutation or cognitive status. As we have previously found, the association between FDG and EYO significantly differs between MC and non-carrier groups (p-value<0.001 and p-value<0.01 for inferior parietal and precuneus, respectively). However, these associations were not significant between ePiB and EYO. Conclusions: Our findings show that ePiB is strongly correlated with FDG within the same individual. However, ePiB does not display the same sensitivity as FDG to reflect disease progression in this population. Further studies are needed to fully determine the utility of ePiB measurements in clinic.