Premium
Sleep duration, cognitive decline, and dementia risk in older women
Author(s) -
Chen JiuChiuan,
Espeland Mark A.,
Brunner Robert L.,
Lovato Laura C.,
Wallace Robert B.,
Leng Xiaoyan,
Phillips Lawrence S.,
Robinson Jennifer G.,
Kotchen Jane M.,
Johnson Karen C.,
Manson JoAnn E.,
Stefanick Marcia L.,
Sarto Gloria E.,
Mysiw W. Jerry
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.03.004
Subject(s) - dementia , hazard ratio , medicine , cognitive decline , cognition , sleep (system call) , depression (economics) , gerontology , proportional hazards model , prospective cohort study , disease , psychiatry , confidence interval , computer science , economics , macroeconomics , operating system
Consistent evidence linking habitual sleep duration with risks of mild cognitive impairment (MCI) and dementia is lacking. Methods We conducted a prospective study on 7444 community‐dwelling women (aged 65–80 y) with self‐reported sleep duration, within the Women's Health Initiative Memory Study in 1995–2008. Incident MCI/dementia cases were ascertained by validated protocols. Cox models were used to adjust for multiple sociodemographic and lifestyle factors, depression, cardiovascular disease (CVD), and other clinical characteristics. Results We found a statistically significant ( P = .03) V‐shaped association with a higher MCI/dementia risk in women with either short (≤6 hours/night) or long (≥8 hours/night) sleep duration (vs. 7 hours/night). The multicovariate‐adjusted hazard for MCI/dementia was increased by 36% in short sleepers irrespective of CVD, and by 35% in long sleepers without CVD. A similar V‐shaped association was found with cognitive decline. Discussion In older women, habitual sleep duration predicts the future risk for cognitive impairments including dementia, independent of vascular risk factors.