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Incidence of dementia and subtypes: A cohort study in four regions in China
Author(s) -
Yuan Jing,
Zhang Zhenxin,
Wen Hongbo,
Hong Xia,
Hong Zhen,
Qu Qiumin,
Tang Mouni,
Wu Jixing,
Xu Qun,
Li Hui,
Cummings Jeffrey L.
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.02.011
Subject(s) - dementia , incidence (geometry) , vascular dementia , hazard ratio , medicine , cohort , china , population , cohort study , demography , gerontology , pediatrics , disease , confidence interval , environmental health , geography , physics , archaeology , sociology , optics
Abstract Introduction There is a dearth of literature on the incidence of dementia in China. Methods Using a stratified, multistage, cluster‐sampling method, 16,921 nondemented participants ≥55 years were recruited from four regional centers in China in 1997 and followed up to 4.5 years. Cases were identified through a three‐step protocol, according to standardized criteria for dementia, Alzheimer's dementia (AD), and vascular dementia (VaD). Results The crude incidence in persons ≥65 years was 12.1/1000 person‐years for dementia, 8.2/1000 person‐years for AD, and 3.1/1000 person‐years for VaD. After adjusting for sociodemographic factors, older age and lower education were associated with a higher risk of incident dementia, AD and VaD; regional difference was associated mainly with incidence of VaD (north vs. south: hazard ratio [HR] = 3.59); modestly with AD (east vs. west: HR = 1.55). Discussion The incidence of dementia in Chinese population is comparable with that in Europe and United States.