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Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI‐Tuscany Study
Author(s) -
Salvadori Emilia,
Poggesi Anna,
Valenti Raffaella,
Pracucci Giovanni,
Pescini Francesca,
Pasi Marco,
Nannucci Serena,
Marini Sandro,
Del Bene Alessandra,
Ciolli Laura,
Ginestroni Andrea,
Diciotti Stefano,
Orlandi Giovanni,
Di Donato Ilaria,
De Stefano Nicola,
Cosottini Mirco,
Chiti Alberto,
Federico Antonio,
Dotti Maria Teresa,
Bonuccelli Ubaldo,
Inzitari Domenico,
Pantoni Leonardo
Publication year - 2016
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.02.010
Subject(s) - operationalization , neuroimaging , neuropsychology , cognitive impairment , dementia , psychology , atrophy , magnetic resonance imaging , medicine , disease , cardiology , audiology , cognition , radiology , neuroscience , epistemology , philosophy
Mild cognitive impairment (MCI) prodromic of vascular dementia is expected to have a multidomain profile. Methods In a sample of cerebral small vessel disease (SVD) patients, we assessed MCI subtypes distributions according to different operationalization of Winblad criteria and compared the neuroimaging features of single versus multidomain MCI. We applied three MCI diagnostic scenarios in which the cutoffs for objective impairment and the number of considered neuropsychological tests varied. Results Passing from a liberal to more conservative diagnostic scenarios, of 153 patients, 5% were no longer classified as MCI, amnestic multidomain frequency decreased, and nonamnestic single domain increased. Considering neuroimaging features, severe medial temporal lobe atrophy was more frequent in multidomain compared with single domain. Discussion Operationalizing MCI criteria changes the relative frequency of MCI subtypes. Nonamnestic single domain MCI may be a previously nonrecognized type of MCI associated with SVD.