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Florbetapir PET, FDG PET, and MRI in Down syndrome individuals with and without Alzheimer's dementia
Author(s) -
Sabbagh Marwan N.,
Chen Kewei,
Rogers Joseph,
Fleisher Adam S.,
Liebsack Carolyn,
Bandy Dan,
Belden Christine,
Protas Hillary,
Thiyyagura Pradeep,
Liu Xiaofen,
Roontiva Auttawut,
Luo Ji,
Jacobson Sandra,
MalekAhmadi Michael,
Powell Jessica,
Reiman Eric M.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2015.01.006
Subject(s) - dementia , positron emission tomography , pittsburgh compound b , magnetic resonance imaging , medicine , standardized uptake value , hippocampal formation , neuroimaging , pathology , cognitive decline , nuclear medicine , oncology , endocrinology , psychology , disease , radiology , psychiatry
Down syndrome (DS) is associated with amyloid b (Ab) deposition. Methods We characterized imaging measurements of regional fibrillar Ab burden, cerebral metabolic rate for glucose (rCMRgl), gray matter volumes (rGMVs), and age associations in 5 DS with dementia (DS/AD1), 12 DS without dementia (DS/AD2), and 9 normal controls (NCs). Results There were significant group differences in mean standard uptake value ratios (SUVRs) for florbetapir with DS/AD1 having the highest, followed by DS/AD2, followed by NC. For [18F]‐fluorodeoxyglucose positron emission tomography, posterior cingulate rCMRgl in DS/AD1 was significantly reduced compared with DS/AD2 and NC. For volumetric magnetic resonance imaging (vMRI), hippocampal volumes were significantly reduced for the DS/AD1 compared with DS/AD2 and NC. Age‐related SUVR increases and rCMRgl reductions were greater in DS participants than in NCs. Discussion DS is associated with fibrillar Ab, rCMRgl, and rGMV alterations in the dementia stage and before the presence of clinical decline. This study provides a foundation for the studies needed to inform treatment and prevention in DS.