z-logo
Premium
Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset
Author(s) -
Barnes Josephine,
Dickerson Bradford C.,
Frost Chris,
Jiskoot Lize C.,
Wolk David,
Flier Wiesje M.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.12.007
Subject(s) - apathy , odds , depression (economics) , cognition , disease , psychosis , odds ratio , logistic regression , medicine , psychiatry , psychology , clinical psychology , economics , macroeconomics
Determining the relationship between age and Alzheimer's disease (AD) presentation is important to improve understanding and provide better patient services. Methods We used AD patient data (N = 7815) from the National Alzheimer Coordinating Center database and multinomial logistic regression to investigate presentation age and first cognitive/behavioral symptoms. Results The odds of having a nonmemory first cognitive symptom (including impairment in judgment and problem solving, language, and visuospatial function) increased with younger age ( P  <.001, all tests). Compared with apathy/withdrawal, the odds of having depression and “other” behavioral symptoms increased with younger age ( P  <.02, both tests), whereas the odds of having psychosis and no behavioral symptom increased with older age ( P  <.001, both tests). Discussion There is considerable heterogeneity in the first cognitive/behavioral symptoms experienced by AD patients. Proportions of these symptoms change with age with patients experiencing increasing nonmemory cognitive symptoms and more behavioral symptoms at younger ages.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here