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Self‐rated and informant‐rated everyday function in comparison to objective markers of Alzheimer's disease
Author(s) -
Rueda Alicia D.,
Lau Karen M.,
Saito Naomi,
Harvey Danielle,
Risacher Shan L.,
Aisen Paul S.,
Petersen Ronald C.,
Saykin Andrew J.,
Farias Sarah Tomaszewski
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.09.002
Subject(s) - disease , psychology , cognition , alzheimer's disease , atrophy , alzheimer's disease neuroimaging initiative , clinical psychology , cognitive impairment , developmental psychology , medicine , psychiatry
It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self‐ versus informant‐report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer's disease). A total of 1080 subjects with self‐ and/or informant‐rated Everyday Cognition questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid abnormalities, and a marker of amyloid deposition using positron emission tomography with [ 18 F]AV45 (florbetapir). Overall, informant‐report was consistently more associated with objective markers of disease than self‐report although self‐reported functional status may still have some utility in early disease.