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Self‐reported sleep disturbance is associated with Alzheimer's disease risk in men
Author(s) -
Benedict Christian,
Byberg Liisa,
Cedernaes Jonathan,
Hogenkamp Pleunie S.,
Giedratis Vilmantas,
Kilander Lena,
Lind Lars,
Lannfelt Lars,
Schiöth Helgi B.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.08.104
Subject(s) - dementia , medicine , logistic regression , sleep (system call) , incidence (geometry) , sleep disorder , disease , alzheimer's disease , proportional hazards model , gerontology , psychiatry , insomnia , physics , computer science , optics , operating system
Objective To study the association between self‐reported sleep disturbances and dementia risk. Methods Self‐reported sleep disturbances and established risk factors for dementia were measured in men at ages 50 (n = 1574) and 70 (n = 1029) years. Dementia incidence was determined by reviewing their patient history between ages 50 and 90 years. In addition, plasma levels of β‐amyloid (Aβ) peptides 1–40 and 1–42 were measured at ages 70, 77, and 82 years. Results Cox regression demonstrated that men with self‐reported sleep disturbances had a higher risk of developing dementia (+33%) and Alzheimer's disease (AD, +51%) than men without self‐reported sleep disturbances (both P < .05). Binary logistic regression showed the increased risk for both dementia (+114%) and AD (+192%) were highest when sleep disturbance was reported at age 70 years (both P < .001). No group differences were found in Aβ levels. Conclusion Improving sleep quality may help reduce the neurodegenerative risk in older men.