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P4‐314: TEST‐RETEST DATA FOR THE TAU PET IMAGING AGENT 18F‐AV‐1451 (PREVIOUSLY, 18F‐T807)
Author(s) -
Devous Michael D.,
Joshi Abhinay D.,
Navitsky Michael A.,
Dickson James,
Pontecorvo Michael A.,
Siderowf Andrew,
Mintun Mark A.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.07.085
Subject(s) - pathology , nuclear medicine , medicine , alzheimer's disease , positron emission tomography , hippocampal formation , entorhinal cortex , reproducibility , neuroscience , psychology , chemistry , disease , chromatography
cingulum, cingulum-hippocampal and superior longitudinal fasciculus (plus temporal branch). To identify areas of significant FC within the DMN, independent component analysis (ICA) was applied to the resting state fMRI scans. FC ROI was defined as the overlap between the grey matter area surrounding the specific DMN fiber tract terminal and the ICA-DMNmap. In a linear regression analysis, tract specificWMH ratio was tested as a predictor of the tract’s FC ROI value, controlled for age, global AV45-PET, diagnosis and education in the pooled group.Results:Higher WMH ratio in the IFOF was associated with decreased FC in the medial prefrontal cortex and the angular gyrus ROIs (t(73) 1⁄4 -2.295, p 1⁄4 .02) across all subjects. The WMH ratios in other tracts of the DMN were not associated with FC. Conclusions: The results suggest that WMH disrupt functional connectivity in a fiber-tract specific way, independent from beta-amyloid. Future research needs to address whether WMH in particular neural networks are associated with specific cognitive deficits.