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P4‐307: REDUCED RESTING STATE FUNCTIONAL CONNECTIVITY ASSOCIATED WITH FDG‐PET HYPOMETABOLISM IN ALZHEIMER'S DISEASE
Author(s) -
SimonVermot Lee,
Araque Caballero Miguel Ángel,
Gesierich Benno,
KambeitzIlankovic Lana,
Duering Marco,
Ewers Michael
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.07.078
Subject(s) - precuneus , resting state fmri , default mode network , medicine , dementia , temporal lobe , neuroscience , positron emission tomography , neuroimaging , alzheimer's disease , psychology , functional connectivity , disease , functional magnetic resonance imaging , epilepsy
that small changes in amyloid predict cognitive change over 3.5 years. Moreover, these effects are detectable earlier in adulthood than is typically examined in amyloid imaging studies of preclinical Alzheimer’s disease (AD). Overall, amyloid most affected episodic memory (Table 1), but other cognitive domains were also impacted. More follow-up is needed to determine whether and when subjects convert to MCI or AD and whether we have detected preclinical AD in middle aged adults many years before symptoms appear.