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P4‐306: EFFECTS OF IN VIVO AMYLOID BURDEN ON COGNITION IN HEALTHY ADULTS AGED 30 TO 89: INITIAL LONGITUDINAL RESULTS ACROSS 3.5 YEARS FROM THE DALLAS LIFESPAN BRAIN STUDY
Author(s) -
Park Denise C.,
Devous Michael D.,
Farrell Michelle E.,
Bischof Gérard Nisal,
Rieck Jenny R.,
Rodrigue Karen M.,
Kennedy Kristen M.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.07.077
Subject(s) - episodic memory , cognition , cognitive decline , psychology , amyloid (mycology) , longitudinal study , pittsburgh compound b , working memory , effects of sleep deprivation on cognitive performance , medicine , audiology , neuroscience , dementia , disease , pathology , cognitive impairment
obtained (figure 1), we calculated regional average ALFF. Results: Compared to controls, aMCI patients showed decreased ALFF in the temporal region; compared to AD, higher values in the PCC but lower in the temporal area. The mild AD group had lower ALFF in the PCC compared to controls (table 1). There was no difference between the connectivity in the aMCI group compared to the other groups, but AD patients showed decreased connectivity in the frontal and PCC (table 2). Also, PCC ALFF correlated to functional connectivity in nearly all sub regions. C ognitive tests correlated to connectivity values but not to ALFF (figure 2). Conclusions: In conclusion, we found that DMN connectivity and ALFF are correlated in these groups. Decreased PCC ALFF disrupts the DMN functional organization, leading to cognitive problems in the AD spectrum.