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P4‐305: STRUCTURAL BRAIN CHANGES IN EARLY‐ONSET ALZHEIMER'S DISEASE SUBJECTS USING THE PIPELINE ENVIRONMENT
Author(s) -
Moon Seok Woo,
Dinov Ivo,
Kim Hui Yeon
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.07.076
Subject(s) - neuroimaging , alzheimer's disease neuroimaging initiative , false discovery rate , dementia , psychology , cognition , brain size , neuropsychology , audiology , medicine , cognitive impairment , neuroscience , disease , magnetic resonance imaging , radiology , biochemistry , gene , chemistry
obtained (figure 1), we calculated regional average ALFF. Results: Compared to controls, aMCI patients showed decreased ALFF in the temporal region; compared to AD, higher values in the PCC but lower in the temporal area. The mild AD group had lower ALFF in the PCC compared to controls (table 1). There was no difference between the connectivity in the aMCI group compared to the other groups, but AD patients showed decreased connectivity in the frontal and PCC (table 2). Also, PCC ALFF correlated to functional connectivity in nearly all sub regions. C ognitive tests correlated to connectivity values but not to ALFF (figure 2). Conclusions: In conclusion, we found that DMN connectivity and ALFF are correlated in these groups. Decreased PCC ALFF disrupts the DMN functional organization, leading to cognitive problems in the AD spectrum.