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The Centiloid Project: Standardizing quantitative amyloid plaque estimation by PET
Author(s) -
Klunk William E.,
Koeppe Robert A.,
Price Julie C.,
Benzinger Tammie L.,
Devous Michael D.,
Jagust William J.,
Johnson Keith A.,
Mathis Chester A.,
Minhas Davneet,
Pontecorvo Michael J.,
Rowe Christopher C.,
Skovronsky Daniel M.,
Mintun Mark A.
Publication year - 2015
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.07.003
Subject(s) - positron emission tomography , nuclear medicine , tracer , pet imaging , scaling , amyloid (mycology) , medicine , mathematics , pathology , physics , nuclear physics , geometry
Although amyloid imaging with PiB‐PET ([C‐11]Pittsburgh Compound‐B positron emission tomography), and now with F‐18‐labeled tracers, has produced remarkably consistent qualitative findings across a large number of centers, there has been considerable variability in the exact numbers reported as quantitative outcome measures of tracer retention. In some cases this is as trivial as the choice of units, in some cases it is scanner dependent, and of course, different tracers yield different numbers. Our working group was formed to standardize quantitative amyloid imaging measures by scaling the outcome of each particular analysis method or tracer to a 0 to 100 scale, anchored by young controls (≤45 years) and typical Alzheimer's disease patients. The units of this scale have been named “Centiloids.” Basically, we describe a “standard” method of analyzing PiB PET data and then a method for scaling any “nonstandard” method of PiB PET analysis (or any other tracer) to the Centiloid scale.