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Subjective cognitive concerns, episodic memory, and the APOE ε4 allele
Author(s) -
Samieri Cécilia,
ProustLima Cécile,
M. Glymour Maria,
Okereke Olivia I.,
Amariglio Rebecca E.,
Sperling Reisa A.,
Rentz Dorene M.,
Grodstein Francine
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.06.012
Subject(s) - episodic memory , apolipoprotein e , cognition , psychology , cognitive decline , effects of sleep deprivation on cognitive performance , depression (economics) , clinical psychology , medicine , psychiatry , dementia , disease , economics , macroeconomics
Background Subjective cognitive concerns may represent a simple method to assess likelihood of memory decline among apolipoprotein E ( APOE ) ε4 carriers. Methods We examined the relationship of self‐reported subjective cognitive concerns, using seven specific cognitive concerns, with memory and memory decline over 6 years among APOE ε4 carriers and non‐carriers from the Nurses' Health Study. Results In both groups, increasing subjective cognitive concern score predicted worse baseline memory and faster rates of subsequent memory decline, after adjustment for age, education and depression. The relation with baseline memory appeared statistically stronger in APOE ε4 carriers ( P ‐interaction = 0.03). For memory decline, mean differences in slopes of episodic memory (95% CI) for 4 to 7 versus no concern = −0.05 (−0.10, 0.01) standard units in APOE ε4 carriers, and −0.04 (−0.08, −0.01) standard units in non‐carriers. Conclusions APOE ε4 carriers with self‐assessed cognitive concerns appear to have worse memory, and possibly accelerated memory decline.