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The Israel Diabetes and Cognitive Decline (IDCD) study: Design and baseline characteristics
Author(s) -
Beeri Michal Schnaider,
RavonaSpringer Ramit,
Moshier Erin,
Schmeidler James,
Godbold James,
Karpati Tomas,
Leroith Derek,
Koifman Keren,
Kravitz Efrat,
Price Rachel,
Hoffman Hadas,
Silverman Jeremy M.,
Heymann Anthony
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.06.002
Subject(s) - dementia , type 2 diabetes , cognition , cognitive decline , medicine , effects of sleep deprivation on cognitive performance , diabetes mellitus , gerontology , population , longitudinal study , prospective cohort study , demography , psychiatry , environmental health , endocrinology , disease , pathology , sociology
Background Type 2 diabetes (T2D) is associated with increased risk of dementia. The prospective longitudinal Israel Diabetes and Cognitive Decline study aims at identifying T2D‐related characteristics associated with cognitive decline. Methods Subjects are population‐based T2D 65+, initially cognitively intact. Medical conditions, blood examinations, and medication use data are since 1998; cognitive, functional, demographic, psychiatric, DNA, and inflammatory marker study assessments were conducted every 18 months. Because the duration of T2D reflects its chronicity and implications, we compared short (0–4.99 years), moderate (5–9.99), and long (10+) duration for the first 897 subjects. Results The long duration group used more T2D medications, had higher glucose, lower glomerular filtration rate, slower walking speed, and poorer cognitive functioning. Duration was not associated with most medical, blood, urine, and vital characteristics. Conclusions Tracking cognition, with face‐to‐face evaluations, exploiting 15 years of historical detailed computerized, easily accessible, and validated T2D‐related characteristics may provide novel insights into T2D‐related dementia.