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P2‐305: ASSOCIATION BETWEEN REDUCED KIDNEY FUNCTION AND COGNITIVE PERFORMANCE IN THE OLDEST OLD: THE HEALTH AND ANEMIA STUDY
Author(s) -
Riva Emma,
Mandelli Sara,
Tettamanti Mauro,
Recchia Angela,
Lucca Ugo
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.984
Subject(s) - cognition , medicine , renal function , population , neuropsychology , statistical significance , anemia , stroop effect , cognitive decline , gerontology , audiology , psychiatry , disease , dementia , environmental health
tiple targets may be more effective than single-target therapies, and make several experimentally testable predictions. These models took into account the dynamic interactions between biological and clinical factors, although the number of clinical factors was highly limited. Conclusions: Systems medicine has not yet been widely applied in the field of dementia research. However, the two computational models identified illustrate the potential of this paradigm to conceptualize dementia in a more realistic fashion. Further research is necessary to develop and validate models that incorporate a wider range of dynamically interacting biological, clinical and environmental factors. Ultimately systems medicine may provide the basis for more targeted multidrug therapies and complex interventions.