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P2‐299: REPRODUCTIVE HORMONES AND COGNITIVE IMPAIRMENT AMONG COMMUNITY‐DWELLING OLDER MEN: THE CONCORD HEALTH AND AGEING IN MEN PROJECT
Author(s) -
Hsu Benjumin,
Cumming Robert,
Naganathan Vasi,
Blyth Fiona,
Handelsman David
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.977
Subject(s) - testosterone (patch) , quartile , sex hormone binding globulin , medicine , cognitive decline , endocrinology , ageing , luteinizing hormone , estrone , hormone , mini–mental state examination , follicle stimulating hormone , dementia , gerontology , androgen , disease , confidence interval
Background: CAIDE Dementia Risk Score is a tool for estimating dementia risk in the general population. Its associations with Alzheimer or vascular neuropathology are not known.Our objectivewas to explore the associations between CAIDE Dementia Risk Score at baseline and neuritic plaques, neurofibrillary tangles, microand macroinfarcts, and cerebral amyloid angiopathy (CAA) after up to 10 years follow-up in the Vantaa 85+ population. Methods: Study population included 116 participants aged 85 years, without dementia at baseline, and with available clinical and autopsy data. Methenamine silver staining was used for b-amyloid and modified Bielschowsky method for neurofibrillary tangles and neuritic plaques. Macroscopic infarcts were identified from cerebral hemispheres, brainstem, and cerebellum slices. Standardized methods were used to determine microscopic infarcts and CAA. Two versions of the CAIDE risk score were calculated: one based on age, gender, BMI, total cholesterol, Systolic Blood Pressure and physical activity (range 0-15 points); and one additionally including APOE4 carrier status (range 0-18 points). Results: A CAIDE score above 12 points (version including APOE) was associated with b-amyloid accumulation and CERAD score: OR (95%CI) was 2.5 (1.1-5.3) and 2.6 (1.1-5.9), respectively; it also tended to relate to Braak stage: OR (95% CI) 2.0 (0.9-4.6). No associations were foundwith infarcts or CAA.Conclusions: In a population of elderly aged 85 years, CAIDE Dementia Risk Score was associated with increased Alzheimer-type pathology, particularly amyloid-b accumulation