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P2‐284: ANEMIA AND MILD COGNITIVE IMPAIRMENT IN A GERMAN GENERAL POPULATION
Author(s) -
Dlugaj Martha,
Eisele Lewin,
Winkler Angela,
Dürig Jan,
BröckerPreuß Martina,
Dragano Nico,
Moebus Susanne,
Jöckel KarlHeinz,
Erbel Raimund,
Weimar Christian
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.962
Subject(s) - anemia , medicine , confidence interval , odds ratio , confounding , logistic regression , population , cognition , cognitive impairment , demography , multivariate analysis , psychiatry , environmental health , sociology
of incident AD across the entire group (HR1⁄41.63, 95%CI: 1.18-2.25, p1⁄40.003). However, this association was not uniformly present in all subgroups. The respective HR of low physical activity regarding AD risk within each group were: CO: 1.7 (95%CI: 0.955-3.03, p1⁄40.072), SCDnw: 2.99 (95%CI: 1.35-6.58, p1⁄40.007), SCDw: 1.27 (95%CI: 0.618-2.63, p1⁄40.512) and MCI: 1.20 (95%CI: 0.673-2.14, p1⁄40.537). Conclusions: Low physical activity is associated with greatest risk increase of AD in individuals with SCDnw. There was no risk modification in the SCDw and MCI group suggesting that physical activity has the greatest protective potential at the stage of early SCD without worries and much less in more advanced at-risk stages of AD such as SCDw and MCI. This is of particular relevance for AD prevention programs.