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P2‐224: EXPECTED IMPACT OF AMYLOID β POSITRON EMISSION TOMOGRAPHY ON DIAGNOSTIC AND TREATMENT DECISIONS FOR SUSPECTED ALZHEIMER'S DISEASE PATIENTS
Author(s) -
Ganz Michael L.,
Tawah Alie F.,
Chitnis Abhishek,
Silies Hedwig,
Schaeuble Barbara,
Foster Norman L.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.901
Subject(s) - dementia , positron emission tomography , medicine , appropriate use criteria , disease , likert scale , alzheimer's disease , neuroimaging , family medicine , psychology , psychiatry , pediatrics , nuclear medicine , developmental psychology
parahippocampal diffusivity (ES>2.0), followed by posterior cingulum (ES1⁄41.5), genu (ES1⁄41.3) and isthmus (ES1⁄41.0). No differences were found betweenMCI/AD. Smaller hippocampal volumes in the patient group were associated with higher hippocampal diffusivity. Diffusivity in the genu predicted decline in the group of MCI-subjects. Conclusions: DTI metrics are more sensitive for group differences than atrophymeasurements. Our results suggest that diffusion changes precede and occur independent of GM atrophy. DTI metrics in the genu are able to predict cognitive decline in MCI.