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P2‐223: MICROHEMORRHAGE FINDINGS ON BASELINE ROSAS MRI DATA
Author(s) -
Basselerie Hubert,
Bracoud Luc,
Schneble HansMartin,
Gouttard Sylvain,
Guignot Isabelle,
Istace Audrey,
Roche Florent,
Schaerer Joel,
Pueyo Maria,
Pachai Chahin,
Vellas Bruno,
Bonneville Fabrice
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.900
Subject(s) - dementia , cognitive impairment , medicine , susceptibility weighted imaging , memory clinic , nuclear medicine , cognitive decline , magnetic resonance imaging , radiology , disease
parahippocampal diffusivity (ES>2.0), followed by posterior cingulum (ES1⁄41.5), genu (ES1⁄41.3) and isthmus (ES1⁄41.0). No differences were found betweenMCI/AD. Smaller hippocampal volumes in the patient group were associated with higher hippocampal diffusivity. Diffusivity in the genu predicted decline in the group of MCI-subjects. Conclusions: DTI metrics are more sensitive for group differences than atrophymeasurements. Our results suggest that diffusion changes precede and occur independent of GM atrophy. DTI metrics in the genu are able to predict cognitive decline in MCI.