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P2‐222: REDUCED CALLOSAL WHITE MATTER INTEGRITY SURPASSES CEREBROSPINAL FLUID AND ATROPHY MARKERS AS PREDICTOR OF DECLINE IN SUBJECTS WITH MILD COGNITIVE IMPAIRMENT: A COMBINED VOLUMETRY AND DTI STUDY
Author(s) -
Clerx Lies,
Jacobs Heidi I.L.,
Gronenschild Ed,
Backes Walter,
OldeRikkert Marcel,
Claassen Jurgen A.,
Barkhof Frederik,
Binnewijzend Maja,
Buchem Mark,
Van der Grond Jeroen,
Visser Pieter Jelle,
Verhey Frans R.J.,
Aalten Pauline
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.899
Subject(s) - cingulum (brain) , splenium , corpus callosum , diffusion mri , white matter , parahippocampal gyrus , medicine , atrophy , fractional anisotropy , psychology , pathology , cardiology , neuroscience , magnetic resonance imaging , radiology , temporal lobe , epilepsy
the increased blood inflow from the arterial-venous shunts; increased looping of distal intracranial arterial branches. The degree of vascular changes severity did not depend on AD stage and was practically the same in all cases. Conclusions: The data obtained suggest that microcirculatory disorders and atrophic phenomena are interrelated, but DAAT phenomena are primary in AD progression and occur long before the disease onset, while atrophic changes are secondary and progress against DAAT during AD.