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P2‐217: DEFAULT‐MODE NETWORK FUNCTIONAL CONNECTIVITY CHANGES IN ALZHEIMER'S DISEASE
Author(s) -
Saka Esen,
Celebi Ozlem,
KarliOguz Kader,
Has Arzu Ceylan,
Elibol Bulent
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.894
Subject(s) - default mode network , posterior cingulate , neuroscience , episodic memory , functional magnetic resonance imaging , resting state fmri , neuropsychology , temporal lobe , psychology , medicine , cognition , epilepsy
and p 181 -tau (R1⁄4 0.48; p1⁄4 0.017), but not A b 42. Lactate was not correlated with any CSF biomarker. The Figure depicts estimatedmarginal means and standard errors from the mixed model.Conclusions: Patients with early AD have higher glucose concentration in an area susceptible to AD pathology compared to controls, perhaps as a result of lower glucose utilization due to neurogeneration. In addition, lactate concentration is higher, suggesting higher regional metabolic reliance on glycolysis. These results motivate the longitudinal study of MRS glucose and lactate as novel AD biomarkers. Acknowledgement: This research was supported entirely by the Intramural Research Program of the NIA/NIH.