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P2‐209: DIFFERENTIAL EFFECT OF AGE ON ALZHEIMER'S DISEASE BIOMARKERS IN COGNITIVELY NORMAL APOLIPOPROTEIN E4 CARRIERS AND NON‐CARRIERS
Author(s) -
Gonneaud Julie,
Fouquet Marine,
ArenazaUrquijo Eider M.,
Perrotin Audrey,
Mézenge Florence,
Landeau Brigitte,
Sayette Vincent,
Eustache Francis,
Desgranges Béatrice,
Chételat Gael
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.886
Subject(s) - apolipoprotein e , neuroimaging , disease , medicine , alzheimer's disease , hippocampus , population , oncology , psychology , pathology , neuroscience , environmental health
demographic factors, cardiovascular risk factors, APOE genotype and white matter hypertintensities (WMH), the mixed effect model revealed that the number of overall lacunes (p<0.001) and volume of WMH (p<0.001) were associated with the change of number of overall CMBs, lobar CMBs and deep CMBs. However, PiB-positivity was not related with the changes of number of overall CMBs (p1⁄40.201), lobar CMBs (p1⁄40.351) and deep CMBs (p1⁄40.292). Then we evaluated changes of CVD (lacunes) with the incident CMBs. The changes of overall lacunes, white matter lacunes and deep grey matter lacunes were significantly associated with the changes of number of overall CMBs and deep CMBs (all p<0.001). However, changes of deep grey matter lacunes were not related with the changes of lobar CMBs (p1⁄40.230) while overall lacunes (p1⁄40.016) and white matter lacunes (p1⁄40.007) were associated with lobar CMBs. Conclusions: The markers of CVD (lacunes and WMH) were related to development of both lobar and deep CMBs while PiB-positivity was not related. Especially, the changes of number of lacunes were associated with the incident CMBs.