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P2‐198: THE DIAGNOSTIC VALUE OF MIBG CARDIAC SCINTIGRAPHY FOR DIFFERENTIAL DEMENTIA DIAGNOSIS
Author(s) -
Engelborghs Sebastiaan,
Slaets Sylvie,
Acker Frank,
Versijpt Jan,
Hauth Lothar,
Martin JeanJacques,
De Deyn Peter Paul
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.874
Subject(s) - dementia with lewy bodies , medicine , dementia , medical diagnosis , cardiology , scintigraphy , diabetes mellitus , differential diagnosis , vascular dementia , disease , radiology , pathology , endocrinology
on a presentation of the information gathered during the clinical diagnostic work-up at enrollment in the study, a panel of three neurologists experienced with dementia made a consensus clinical dementia diagnosis. The panel was provided with clinical information, such as date of birth, age and gender, history of past illnesses, social history, onset and history of presenting complaint, familial history, medication, physical examination, clinical neurological examination, neuropsychological examination including (amongst others) Mini-Mental State Examination scores (MMSE), brain CT and/or MRI scan. Clinical diagnosis was based on standard clinical diagnostic criteria, allowing the panel to label each clinical diagnosis as probable or possible depending on the likelihood of it being the cause of dementia. All pathological diagnoses were established by the same neuropathologist, who was blinded for the clinical diagnostic results, according to standard neuropathological criteria. Results: Forty-two patients in the population (59%) appeared to have definite AD, whereas 29 (41%) patients had a non-AD dementia The panel clinically diagnosed possible or probable VaD in 27 out of 71 (38%) patients (with or without a concomitant neurodegenerative dementia like AD). Of those 27 patients, diagnosis of VaD was neuropathologically confirmed in only five (19%) patients (p1⁄40.017). Conclusions: In this study, patients with vascular lesions observed with structural brain imaging were often misdiagnosed as a dementia with a presumed clinically significant vascular component as compared to the neuropathological dementia diagnosis. After neuropathological confirmation, the majority of these patients were diagnosed with other dementia types than VaD.