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P2‐160: PRESENTATION OF AFFECTIVE AND DISRUPTIVE CLUSTERS OF NEUROPSYCHIATRIC SYMPTOMS IN SINGAPORE
Author(s) -
Koay Way Inn,
Tay Sze Yan,
Gabriel Christopher,
Doshi Kinjal,
Seng Ting Simon Kang,
Hameed Shahul
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.836
Subject(s) - dementia , affect (linguistics) , distress , mood , memory clinic , medicine , clinical psychology , cognition , outpatient clinic , psychiatry , disease , psychology , communication
(Mean/SD) was 6.50 (5.49). According to their MADRS scores, the sample was composed of mild to moderate depressed patients. Seventy percent of the sample had late onset depression. Their mean MMSE, CAMCOG, B-ADL scores were respectively 24.90 (64.19), 81.87 (615.47) and 2.44 (61.13). The Small Volume Correction Tool (SVC) showed positive correlations between GM volumes and MMSE (Right Inferior Temporal Gyrus, p1⁄40.026, 209 voxels) and between GM volumes and CAMCOG (Right Inferior Temporal Gyrus, p1⁄40.004, 471 voxels) and Left Inferior Temporal Gyrus (p1⁄40.026, 114 voxels). No negative correlations were found. Conclusions: These findings highlight the relationship between cognitive performance and volumes of temporal structures in elderly depressed individuals. The positive correlation between MMSE and CAMCOG scores with temporal volumes specifically in elderly depressed individuals provides support to the view that at least a subtype of depression in the elderly may be a risk factor or a prodomic syndrome for AD.