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P2‐122: ULTRASENSITIVE DETECTION OF NEURODEGENERATIVE BIOMARKERS IN BLOOD WITH THE FULLY AUTOMATED SIMOA ANALYZER: CLINICAL APPLICATIONS
Author(s) -
Jeromin Andreas,
Randall Jeff,
Wilson David,
Blennow Kaj,
Zetterberg Henrik
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.797
Subject(s) - concussion , medicine , cerebrospinal fluid , detection limit , biomarker , neurodegeneration , disease , chemistry , chromatography , biochemistry , poison control , environmental health , injury prevention
Plasma Tau was significantly higher in post-concussion samples compared with pre-season samples (p=0.0005). Circulating plasma Tau levels were significantly elevated compared with pre-season levels at the observed post-concussion timepoints (see Fig. 2 for p values). Overall mean plasma Tau dropped 30% (significant at p=0.0011), from 18.59 pg/mL to 13.24 pg/mL during the first 12-hour period, with approximately 40% of donors exhibiting a > 2-fold drop. 20/25 donors exhibited a Tau drop within 12 hours, while 4/25 donors exhibited an increase. Further declines in plasma Tau were not statistically significant between 12 hours and 6 days (p=0.155).