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P2‐050: CHANGES IN THE HUMAN HIPPOCAMPAL PROTEOME DURING ALZHEIMER'S DISEASE
Author(s) -
Hondius David,
Nierop Pim,
Li Ka Wan,
Hoozemans Jeroen,
Schors Roel,
Haastert Elise,
Vies Saskia M.,
Rozemuller Annemieke,
Smit Guus
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.723
Subject(s) - proteome , subiculum , laser capture microdissection , hippocampal formation , proteomics , biology , alzheimer's disease , disease , chemistry , microbiology and biotechnology , pathology , dentate gyrus , biochemistry , neuroscience , medicine , gene expression , gene
Research question and background Because of the current lack of effective treatment and early presymptomatic diagnostic markers of Alzheimer’s disease (AD), detailed insight into disease mechanisms involved at the various stages of AD is highly important. The pathological hallmarks, amyloid beta plaques and intra cellular aggregation of hyperphosphorylated tau in neurofibrillary tangles, are used to objectively stage the disease. In this study we have analysed the proteome of the hippocampus, and in particular the CA1 region and subiculum, as this is one of the most vulnerable and early affected regions in AD, with the aim to identify changes in the human proteome and underlying disease mechanisms.