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P2‐033: GWAS IN AN EASTERN CANADIAN POPULATION ISOLATE LEADS TO NOVEL GENETIC RISK VARIANTS IN GENES ASSOCIATED WITH SYNAPTIC REMODELLING
Author(s) -
Frappier Josée,
Miron Justin,
Dea Doris,
Theroux Louise,
Picard Cynthia,
Lalonde Daphne,
Poirier Judes
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.706
Subject(s) - single nucleotide polymorphism , genome wide association study , biology , population , population stratification , genetics , logistic regression , demography , gene , medicine , genotype , sociology
were 1.05 for cases and 0.85 for controls (p<2 x 10-16). Of particular interest is that the Amish cases and the general population cases were also significantly different (0.94 vs 1.05, p1⁄42.5 x 10-6). The Amish controls (0.86) and general population controls (0.85) were not significantly different. Conclusions: The Amish cases carry a higher burden of LOAD loci than the Amish controls, but this burden is much lower than in the general population. Thus the genetic architecture of LOAD in the Amish is different than the general Caucasian population and suggests that additional loci can be discovered.