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P2‐016: NEUROPATHOLOGICAL, NEUROPSYCHOLOGICAL, AND IMAGENOLOGICAL COMPARISON BETWEEN SPORADIC ALZHEIMER'S DISEASE AND PS1‐E280A
Author(s) -
TrujilloRodríguez Diana Marina,
SepúlvedaFalla Diego,
Arboleda Humberto,
Glatzel Markus,
Lopera Francisco
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.689
Subject(s) - neuropsychology , cerebellum , atrophy , temporal cortex , neuroscience , cortex (anatomy) , psychology , alzheimer's disease , hippocampal formation , cerebral cortex , cerebellar cortex , pathology , medicine , disease , audiology , cognition
Background: In this descriptive study of a case series a comparison was made of neuropathological, neuropsychological and imaging characteristics from two groups of patients with Alzheimer’s Disease (AD). One group with sporadic AD (SAD) and another group with familial AD (FAD). Methods: For that, 460 deparaffinized slides from brain tissue were obtained, together with clinical and imaging registries from the Brain Bank of the Neurosciences group of the University of Antioquia. Results: In the neuropathological comparison it was observed that SAD presents more but smaller A b deposits in temporal and occipital cortex compared with FAD. Also, SAD shows correlation between disease duration and neurofibril pathology in temporal cortex. FAD cases present larger deposits in frontal, temporal, parietal and cerebellar areas; together with higher A b immunosignal in the cerebellum. Regarding hyperphosphorylated Tau (pTau) quantification, FAD presents with higher levels in frontal, parietal, occipital and cerebellar areas. Also, It was observed correlations between brain weight, disease duration and pTau in temporal cortex in FAD. In the neuropsychological comparison there were significant differences in total scores for memory, particularly in immediate and long term recovery in a word list task. Imaging comparison showed no differences in cortical atrophy, hippocampal atrophy, fimbriosubicular distance and interuncal distance. Conclusions: In conclusion, there are neuropathological differences between FAD and SAD that could be related with the physiopathology of this hereditary variant of AD. P2-017 THE EFFECT OF KAMI-UNTAN-TOU ON BETAAMYLOID PROTEIN-INDUCED APOPTOSIS IN PC12 CELLS