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P1‐421: DISTINCT ROLE OF ESTRADIOL STEREOISOMERS ON SCOPOLAMINE‐INDUCED MEMORY IMPAIRMENT IN POSTMENOPAUSAL RATS
Author(s) -
Bansal Seema,
Kaur Sukhneerajpaul,
Chopra Kanwaljit
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.664
Subject(s) - ovariectomized rat , estrogen , menopause , morris water navigation task , endocrinology , medicine , memory impairment , psychology , cognition , hippocampus , psychiatry
the combination of subeffective concentrations of melatonin and galanthamine show a synergic neuroprotective effect and reduce most of the alterations observed in our toxic model that combines Ab/OA. Conclusions: Taken together, our results show that the combination of subtoxic concentrations of Ab and O.A in OHCs reproduces many of the histopathological alterations found in AD. Using this in vitro AD model, melatonin in combination with lower doses of ACE inhibitors afforded significant protection and prevention of AD pathological markers. We therefore propose that melatonin replacement in addition to low doses of ACE inhibitors could be an interesting strategy for AD.