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P1‐408: TARGETING SYNAPTIC DYSFUNCTION THROUGH DIETARY POLYPHENOL AS A NOVEL THERAPEUTIC INTERVENTION FOR AD
Author(s) -
Wang Jun,
Pasinetti Giulio Maria
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.651
Subject(s) - long term potentiation , synaptic plasticity , polyphenol , neurotransmission , neuroscience , pharmacology , cognitive decline , dementia , hippocampal formation , medicine , chemistry , biology , biochemistry , disease , antioxidant , receptor
of ChAT and Ach inside hippocampus of mice. Results: Step down test showed small and medium-dose GEPT treatment improved mice performance to normal level. From the second day to the fifth day, the latent time of the model group, compared with the normal group, had significant increase. Donepezil group, small and medium dose GEPT group, compared with the model group, had significant decrease in the third day and fourth day. In Space exploration experiment, the time spent in target quadrant of medium-dose GEPT group, compared to model group, was significantly increased. Western blot showed that ChAT in hippocampus of model group was significantly decreased compared to normal group, while ChAT content of Donepezil, medium and high dose GEPT groups all increased. Meanwhile, AChE content is relatively high in model group, and low in small and medium dose GEPT groups. Conclusions: APP/PS1 mice suffered from cognitive and behavioral impairment in ninemonths, and accompanied by decreased ChATand increased AChE in hippocampus. While, GEPT can effectively relieve the cognitive and behavioral dysfunction of APP/PS1 mice via restore the balance of ChAT/AChE.