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P1‐357: ADCS EDC: INVESTIGATIONAL PRODUCT MANAGEMENT SYSTEM
Author(s) -
JimenezMaggiora Gustavo Adolfo,
Thomas Ronald G.,
Qiu Hongmei,
Hong Phuoc,
Aisen Paul S.
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.599
Subject(s) - timeline , electronic data capture , clinical trial , informatics , data management , process management , computer science , quality assurance , systems engineering , medicine , engineering , operations management , database , external quality assessment , archaeology , pathology , electrical engineering , history
comprehension). Results: PCA patients’ mean reading accuracy for normal passage text was 57.2% in contrast to near-ceiling accuracy in typical AD patients (97.5%) and healthy controls (99.4%); spatial aspects of text were the primary determinants of passage reading ability in PCA (see Figure 1). PCA patients made more saccades, more fixations and longer fixations than typical AD patients (p<.05) and healthy controls (p<.005; see Table 1). The interventions led to considerable and consistent gains in PCA patients’ reading accuracy (both p<.001). Under the single-word intervention, mean reading accuracy increased from 57.2% to 95.6%. PCA patients’ fixations were of increased duration and saccades were of decreased amplitude (both p<.05). Both interventions also resulted in improvements on selfrated measures of reading (ease: both p<.005; comprehension: both p<.005; pleasantness; both p<.05). Conclusions: Findings highlight the contribution of various visual and oculomotor deficits in limiting reading above the single-word level in PCA and provide a basis for developing software-based reading aids.