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P1‐335: A SIMPLE TEST OF EPISODIC MEMORY PREDICTS CONVERSION TO DISEASE (MCI/AD) A DECADE LATER: DATA FROM THE WOMEN's HEALTHY AGEING PROJECT (WHAP)
Author(s) -
Szoeke Cassandra,
Robertson Joanne S.,
Lehert Philippe,
Rowe Christopher Cleon,
Masters Colin Louis,
Ames David,
Dennerstein Lorraine,
Desmond Patricia
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.576
Subject(s) - cohort , dementia , disease , medicine , episodic memory , alzheimer's disease neuroimaging initiative , cognition , cognitive decline , memory clinic , gerontology , psychology , psychiatry
the words produced by younger adults and older adults. Nine of the categories (3 living categories, 3 non-living categories and 3 mixed categories) least influenced by normal ageing were then selected to be administered to patients with MCI prodromal to AD. Conclusions: Performance on the altered version of the CFT is unaffected by normal ageing effects and will further help in understanding the automatic and executive semantic impairment in pathological ageing due to AD. It may also be more sensitive to the earliest preclinical and presymptomatic changes caused byADwhen applied in patients with MCI. The practical implications for diagnosis of this modified neuropsychological instrument are important since it will improve the identification of people at risk during the earliest stage of the disease before irreversible neural damage occurs. This will allow for timely therapeutic intervention should disease modifying drugs become available in the future.