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P1‐323: SLEEP‐RELATED FEATURES AND PERFORMANCE ON A COMPUTERIZED COGNITIVE BATTERY: THE MAYO CLINIC STUDY OF AGING
Author(s) -
Boeve Angelica,
Mielke Michelle M.,
Geda Yonas,
Roberts Rosebud O.,
Ivnik Robert,
Machulda Mary M.,
Fields Julie A.,
Pankratz Ver,
Boeve Bradley F.,
Knopman David S.,
Petersen Ronald
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.564
Subject(s) - epworth sleepiness scale , alertness , psychology , audiology , effects of sleep deprivation on cognitive performance , population , cognition , excessive daytime sleepiness , cognitive test , clinical psychology , medicine , sleep disorder , psychiatry , polysomnography , apnea , environmental health
to detecting cognitive changes associated with high A b. However, the apolipoprotein E (APOE) ε4 allele was unrelated to the rate of Ab-related memory decline in these studies. This is surprising, as in vitro studies have indicated a role for apoE in increasing Ab accumulation and reducing its clearance. One interpretation of these findings is that the 4-related risk for AD is only an indirect estimate of the risk for AD posed by high Ab, or that extant studies recruited small samples and conducted follow-up assessments that were too brief. Thus, this study aimed to determine the utility of the Cognigram brief battery in characterizing cognitive decline associated with Ab and APOE ε4 in a larger sample of healthy, non-demented older adults over a 54-month period of time. Methods: Healthy adults (n1⁄4333) enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study underwent Ab neuroimaging. The Cognigram brief battery was administered at baseline, 18-, 36and 54-month follow-ups. Ab PET neuroimaging was used to classify participants as Ab or Ab and APOE genotype was ascertained from blood samples. Results: Relative to the Ab ε4 group, the Abε4 group showed significantly faster rates of cognitive decline across all domains over the 54-month study period (d 1⁄40.450.72); Abε4 individuals did not show significantly faster decline on any cognitive measure. There were also no differences in rates of cognitive change between Ab ε4 and Ab ε4 groups. Conclusions: Results of this study suggest that the Cognigram brief battery is a useful tool that may be used to monitor subtle cognitive changes associated with Ab and APOE ε4 in otherwise healthy, non-demented older adults.