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P1‐316: COMBINED STAGING OF ALZHEIMER'S AND CEREBROVASCULAR PATHOLOGY EXPLAINS COGNITIVE VARIABILITY IN A COHORT OF PATIENTS WITH ADVANCED DEMENTIA
Author(s) -
ZeaSevilla M. Ascension,
FernándezBlázquez Miguel Angel,
BermejoVelasco Pedro,
RábanoGutierrez Alberto
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.557
Subject(s) - dementia , vascular dementia , medicine , pathology , neuropathology , alzheimer's disease , disease , etiology , psychology
a Adjusted for by ACT study data (cohort, age at death, gender, education and history of smoking) and medical record review data (hypertension, diabetes, and atrial fibrillation any time prior to death and BMI based on the height and weight found in the chart closest to age 65). b Weighted for selection to autopsy. Selection model included the following covariates (as of last ACT follow-up): ACT study cohort, age, gender, education, dementia status, history of smoking, atrial fibrillation, cerebrovascular disease, and coronary artery disease. For the selection model, information on age, gender, education, smoking, dementia, history of cerebrovascular disease and coronary artery disease were based on ACT self-reported study data, and history of atrial fibrillation was based on presence of administrative data codes indicating atrial fibrillation anytime in the 5 years prior to last ACT follow-up. Any subjects missing selection model covariates were excluded from analyses. c Bias-corrected and accelerated confidence intervals and p-values were computed using the bootstrap to account for uncertainty introduced by estimation of selection weights. Poster Presentations: P1 P427