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P1‐308: COLLAGENOSIS OF THE DEEP MEDULLARY VEINS CORRELATES WITH PERIVENTRICULAR WHITE MATTER CHANGES IN ALZHEIMER'S DISEASE
Author(s) -
Gao Fuqiang,
Keith Julia,
Noor Raza,
Kiss Alex,
Black Sandra
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.549
Subject(s) - arteriolosclerosis , medicine , pathology , hyperintensity , white matter , cerebral amyloid angiopathy , leukoaraiosis , autopsy , neuropathology , dementia , cardiology , magnetic resonance imaging , radiology , disease
Decline in the Elderly (IQCODE) scales were used for dementia classification. Dementia was the dependent variable and assigned when participants had CDR 1 and IQCODE 3.4. Perirenal, omentum, mesocolonic and mesenteric fats were weighted in a high precision electronic scale and the total visceral fat was used as the independent variable. Multivariate logistic regression adjusted for age, sex, race, schooling, marital status, smoking, alcohol use, physical activity, hypertension, diabetes, dyslipidemia, coronary artery disease, heart disease, and stroke was applied. Results: Participants had mean age of 71.2613.3 years, 57.4% were male, and 61.6% were White. Dementia prevalence was 20.0%. Mean total visceral fat was 191561240g. Each one unit increase in total visceral fat was associated with a 1% decrease in the odds of dementia (OR1⁄40.998, 95% CI 0.998-0.999; p<0.0001). Conclusions: Total visceral fat was inversely associated with the dementia frequency in our clinicopathological study. Malnutrition related to dementia may be the underlying pathophysiological explanation for our findings.