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P1‐263: ABERRANT FUNCTIONAL CONNECTIVITY OF THE THALAMUS IN A ONE‐YEAR FOLLOW‐UP STUDY OF MILD COGNITIVE IMPAIRMENT
Author(s) -
Zhou Bo,
Zhang Xi,
Guo Yane,
Wang Pan,
Shang Yanchang
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.503
Subject(s) - thalamus , neuropsychology , resting state fmri , default mode network , functional connectivity , psychology , montreal cognitive assessment , functional magnetic resonance imaging , cognition , neuroscience , cognitive impairment , audiology , medicine , cardiology
frontal cortex were activated in HC, but not in AD groups. With new>old, activation in the right operculum, right insular, and the right inferior prefrontal cortices was seen in HC, but not in AD. Unilateral activation was observed in HC in the occipital cortex (left) and the supramarginal gyrus (right); these regions were bilaterally activated in AD. The AD group also showed increased activation in the right dorsal medial portion of the frontal pole, which was not observed in the HC group. Conclusions: Subjects with early AD did not involve certain key structures in normal episodic memory processing as seen in HC, but recruited additional neural circuits especially in the prefrontal cortex. Our study provides the firstMEG dataset confirming a possible neuropathological and neurocompensatory interplay in early AD.