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P1‐258: CORTICAL PHASE CHANGES AT 7T MRI IN SUBJECTIVE COGNITIVE IMPAIRMENT AND THEIR ASSOCIATION WITH COGNITIVE FUNCTION
Author(s) -
Rooden Sanneke,
Buijs Mathijs,
Versluis Maarten,
Webb Andrew,
Flier Wiesje M.,
Scheltens Philip,
Barkhof Frederik,
Buchem Mark,
Grond Jeroen
Publication year - 2014
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2014.05.498
Subject(s) - stroop effect , psychology , neuropsychology , cognition , audiology , magnetic resonance imaging , wechsler adult intelligence scale , neuroscience , medicine , radiology
Background: Studies have suggested that in subjects with subjective cognitive impairment (SCI), Alzheimer like changes may occur in the brain.The accumulation of Alzheimer-associated pathology has been known to precede clinical symptoms by as many as two decades. Recently, an in vivo study has indicated the potential of ultra-high field magnetic resonance imaging (MRI) to visualize amyloid-b-associated changes in the cortex in patients with Alzheimer’s disease (AD), expressed by a phase shift on T 2*-weighted MRI scans. The main aim of the present study was to investigate whether differences in phase shift could be determined in subjects with SCI. The secondary aim was to investigate which parts of the neuropsychological spectrum are associated with cortical phase shifts in SCI subjects. Methods: 28 AD patients, 18 subjects with SCI and 27 healthy control (HC) subjects (table 1) were scanned at 7Tusing a 2D transverse T 2*-weighted scan with a total imaging duration of 10 minutes. MRI scans were analyzed quantitatively by measuring cortical phase shifts in the frontal, parietal, and left and right temporoparietal regions and the whole brain phase shift (expressed in radians) between cortical gray and subcortical white matter (WM) was calculated in each subject. All subjects underwent extended neuropsychological testing including a Mini Mental State Examination (MMSE), Cambridge Cognitive Examination (CAMCOG), Wechsler Memory Scale (WMS), Trailmaking Test (TMT), a Stroop test, and a Geriatric Depression Scale (GDS). Univariate general linear modeling and linear regression analysis (Bonferroni corrected, p<0.007) were used to assess the association between diagnosis and cortical phase shift, and the different neuropsychological tests and phase shift in the SCI group respectively, adjusted for age and gender. Results: Although AD patients demonstrated an increased cortical phase shift compared to healthy control subjects (p<0.001), no such effect was found for subjects with SCI. A significant association was found between memory function (WMS) and cortical phase shift in SCI subjects. Conclusions: Our data show that although in SCI subjects an increased cortical phase shift at high field is associated with poorer memory performance, no increased phase shift could be determined in SCI subjects compared to controls.